On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells
AUTOR(ES)
Martin, Bruno
FONTE
The National Academy of Sciences
RESUMO
CD4+ T cells expand after transfer into lymphopenic H-2b Aβ−/− mice (I-Aβ-, I-Eα-deficient mice) but not after transfer into lymphopenic MHC IIΔ/Δ mice (I-Aα-, I-Aβ-, I-Eα-, and I-Eβ-deficient mice), implying that in H-2b Aβ−/− mice, Aα chain and Eβ chain associate to form a hybrid AαEβ MHC class II molecule. In light of this unexpected result, we reexamined the MHC class II requirement in the survival and lymphopenia-induced proliferation of CD4+ T cells. Here we show that expansion, but not short-term survival, of CD4+ T cells depends on interactions with MHC class II molecules in lymphopenic mice. Nevertheless, interactions with classical MHC class II molecules are required for CD4+ T cells to survive in CD8+ T-cell-containing mice.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=156319Documentos Relacionados
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