Oncornavirus-like particles in human skin cancers.
AUTOR(ES)
Balda, B R
RESUMO
A high-molecular-weight RNA encapsulated with an RNA-instructed DNA polymerase in particles possessing the density characteristic of the RNA tumor viruses has been detected in 13 out of 14 human malignant melanomas. The [3H]DNA synthesized by these particles in an endogenous reaction hybridizes to RNA extracted from the human melanoma particulate structures, but not to RNA from normal skin. Similar particles containing RNA and enzyme have been found in basal cell and squamous cell carcinomas of the skin. The RNA of the melanoma particles is easily distinguishable by hybridization from the RNAs found in the particles of the basal and squamous cell carcinomas.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=433064Documentos Relacionados
- Oncornavirus-like particles released from arginine-deprived human lymphoblastoid cell lines.
- Oncornavirus-like particles from cultured bone marrow cells preceding leukemia and malignant histiocytosis.
- Transformation of cultured human embryonic fibroblasts by oncornavirus-like particles released from a human carcinoma cell line.
- Relationships between intracisternal type A and extracellular oncornavirus-like particles produced in murine MOPC-460 myeloma cells.
- Characterization of the proteins of intracisternal type A and extracellular oncornavirus-like particles produced by MOPC-460 myeloma cells.
