Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene.
AUTOR(ES)
Farnham, P J
RESUMO
We have characterized a transcription unit in the 5' flanking region of the mouse gene encoding dihydrofolate reductase (EC 1.5.1.3) that is oriented in the opposite direction to that of dihydrofolate reductase transcription. These opposite-strand RNAs are 180-240 nucleotides long, differing in length at their 5' ends. They are abundant in nuclear RNA and are not polyadenylylated. We suggest that the promoter region of the dihydrofolate reductase gene functions in a bidirectional manner to produce both these RNAs and dihydrofolate reductase mRNAs.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=397917Documentos Relacionados
- Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.
- The 5' flanking region of human epsilon-globin gene.
- The nucleotide sequence of the 5' flanking region of a tomato polygalacturonase gene.
- Identification of a TFIIIA binding site on the 5' flanking region of the TFIIIA gene.
- Characterization of the 5' flanking region of the human D1A dopamine receptor gene.