Optimal Dose of Amoxicillin in Treatment of Otitis Media Caused by a Penicillin-Resistant Pneumococcus Strain in the Gerbil Model
AUTOR(ES)
Parra, Araceli
FONTE
American Society for Microbiology
RESUMO
Amoxicillin at doses of 0.2 to 5 mg/kg of body weight was administered for the treatment of pneumococcal otitis media in a gerbil model. Doses greater than or equal to 2.5 mg/kg, which resulted in concentrations in middle ear fluid of ≥1.4 μg/ml and concentrations in serum higher than the MIC (1 μg/ml) for ≥14% of the dosing interval, were both clinically and bacteriologically effective.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=127470Documentos Relacionados
- In Vivo Efficacies of Amoxicillin and Cefuroxime against Penicillin-Resistant Streptococcus pneumoniae in a Gerbil Model of Acute Otitis Media
- Effect of increased dosages of amoxicillin in treatment of experimental middle ear otitis due to penicillin-resistant Streptococcus pneumoniae.
- Development of a New Experimental Model of Penicillin-Resistant Streptococcus pneumoniae Pneumonia and Amoxicillin Treatment by Reproducing Human Pharmacokinetics
- Endocarditis caused by relatively penicillin-resistant Stomatococcus mucilaginosus.
- Management of meningitis caused by penicillin-resistant Streptococcus pneumoniae.
