Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope

AUTOR(ES)

Schirmer, Eric C

FONTE

BioMed Central

RESUMO

Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope.

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