Origin of the genetic code: a testable hypothesis based on tRNA structure, sequence, and kinetic proofreading.
AUTOR(ES)
Hopfield, J J
RESUMO
We hypothesize that the origin of the genetic code is associated with the structure of the tRNA that existed in primal cells. The sequences of modern tRNA contain correlations which can be understood as "fossil" evidence of the secondary structure of primal tRNA. Kinetic proofreading through diffusion can amplify a low level of intrinsic selectivity of tRNA for its amino acid. Experimental tests of the theory are suggested.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=336109Documentos Relacionados
- Origin of genetic code: A needle in the haystack of tRNA sequences.
- Experimental evidence for kinetic proofreading in the aminoacylation of tRNA by synthetase.
- On the evolution of accuracy and cost of proofreading tRNA aminoacylation.
- On the evolution of accuracy and cost of proofreading tRNA aminoacylation
- PLMItRNA, a database on the heterogeneous genetic origin of mitochondrial tRNA genes and tRNAs in photosynthetic eukaryotes
