OXIDATIVE PHOSPHORYLATION: THERMODYNAMIC CRITERIA FOR THE CHEMICAL AND CHEMIOSMOTIC HYPOTHESES*
AUTOR(ES)
Caplan, S. R.
RESUMO
Oxidative phosphorylation is analyzed by means of nonequilibrium thermodynamics. It is shown that a mitochondrial system may be characterized in terms of the externally fixed affinities (negative free energies) for oxidation and phosphorylation Aoex and Apex, without knowledge of internal activities. If the electrochemical potential difference of H+ is also fixed, a decision can be made between the chemiosmotic and chemical hypotheses. The chemiosmotic hypothesis is shown to be a limiting case of the chemical hypothesis. In general the P/O ratio cannot be expected to be constant, but will vary with Apex/Aoex; for certain ranges the variation may be marked.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=286149Documentos Relacionados
- Chemiosmotic energy conversion of the archaebacterial thermoacidophile Sulfolobus acidocaldarius: oxidative phosphorylation and the presence of an F0-related N,N'-dicyclohexylcarbodiimide-binding proteolipid.
- The ins and outs of protein phosphorylation: Workshop report: Control of signaling by protein phosphorylation
- Studies on the mechanism of oxidative phosphorylation: effects of specific F0 modifiers on ligand-induced conformation changes of F1.
- Studies of the mechanism of oxidative phosphorylation: Effects of specific F0 modifiers on ligand-induced conformation changes of F1
- Thermodynamic criteria for high hit rate antisense oligonucleotide design