p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.
AUTOR(ES)
Hamaguchi, M
RESUMO
Transformation of chick embryonic fibroblasts with Rous sarcoma virus strongly suppresses N-cadherin-mediated cell-cell adhesion, without inhibiting its expression. This suppression is correlated with tyrosine phosphorylation of N-cadherin and catenins, the cadherin-associated proteins, which are known to regulate cadherin function. Experiments with non-myristylation and temperature-sensitive mutants of RSV and with herbimycin A, a potent inhibitor of tyrosine kinases, suggest that both the suppression of cell adhesion and tyrosine phosphorylation of catenins are highly transformation-specific.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=413207Documentos Relacionados
- Specific proteolytic fragmentation of p60v-src in transformed cell lysates.
- Biochemical properties of p60v-src mutants that induce different cell transformation parameters.
- Processing of p60v-src to its myristylated membrane-bound form.
- Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters.
- CDC37 is required for p60v-src activity in yeast.
