Papel dos ácidos graxos na função e morte de neutrófilos de humanos: utilização do exercício intenso como modelo. / Role of fatty acids in human neutrophil function and death: intense exercise as a model.
AUTOR(ES)
Adriana Cristina Levada Pires
DATA DE PUBLICAÇÃO
2008
RESUMO
The objective of this study was to evaluate the effect of triathlon competition on function and death of neutrophils from elite athletes and to investigate the involvement of fatty acids in this process. Neutrophils were obtained from blood collected from eleven sedentary volunteers and twelve triathletes under rest and after a Half Ironman triathlon competition (2 Km swimming, 80 Km cycling and 20 Km running). The triathlon competition increased the migration and reactive oxygen species production in neutrophils, however it reduced the phagocytosis activity. Moreover, it induced neutrophils death possibly by apoptosis as indicated by DNA fragmentation and phosphatidylserine externalization. The increase in plasma levels of oleic, linoleic and stearic acids induced by the competition may be involved in modulation on neutrophil function and death.
ASSUNTO(S)
Ácidos graxos triatlo triathlon neutrophils apoptosis fatty acids apoptose neutrófilos
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