Paradoxical Action of Penicillin G on Staphylococcus aureus: a Time Study of the Effect of a Zonal Antibiotic Concentration Gradient on Bacterial Growth
AUTOR(ES)
Yourassowsky, E.
RESUMO
The killing rate of a zonal concentration gradient of penicillin G on Staphylococcus aureus was studied by using a previously described triple-layer technique, enzymatic inactivation of the antibiotic, and an automatic image analyzer. This gradient determines a target image, whose center is the reservoir of antibiotic (constituted by a paper disk containing 100 U of penicillin G) and whose successive concentric zones are: a zone of slow bactericidal activity (corresponding to high levels of penicillin G), a zone of maximal bactericidal activity (corresponding to optimal levels of penicillin G), and a zone of overgrowth situated in front of the antibiotic wave.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429303Documentos Relacionados
- Mode of Action of Penicillin: I. Bacterial Growth and Penicillin Activity—Staphylococcus aureus FDA
- Serum inhibits penicillin-induced L-form growth in Staphylococcus aureus: a note of caution on the use of serum in cultivation of bacterial L-forms.
- Effect of storage and changes in bacterial growth phase and antibiotic concentrations on antimicrobial tolerance in Staphylococcus aureus.
- Minocycline Resistance in Staphylococcus aureus: Effect on Phage Susceptibility
- Mechanism of Penicillin-Erythromycin Synergy on Antibiotic-Resistant Staphylococcus aureus
