Paradoxical Growth of Candida dubliniensis Does Not Preclude In Vivo Response to Echinocandin Therapy ▿

AUTOR(ES)

Mariné, Marçal

FONTE

American Society for Microbiology (ASM)

RESUMO

Candida dubliniensis commonly shows paradoxical or trailing growth effects in vitro in the presence of echinocandins. We tested the in vitro activities of anidulafungin, caspofungin, and micafungin against clinical isolates of C. dubliniensis and evaluated the efficacy of these drugs in two murine models of systemic infection. The three echinocandins were similarly effective in the treatment of experimental disseminated infections with C. dubliniensis strains showing or not showing abnormal growth in vitro.

Documentos Relacionados

• Acute hepatitis complicating parenteral amiodarone does not preclude subsequent oral therapy.
• A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo.
• In Vitro Susceptibilities of Candida dubliniensis Isolates Tested against the New Triazole and Echinocandin Antifungal Agents
• Fluconazole treatment of Candida albicans infection in mice: does in vitro susceptibility predict in vivo response?
• Failure To Cleave Murine Leukemia Virus Envelope Protein Does Not Preclude Its Incorporation in Virions and Productive Virus-Receptor Interaction