Parameters of the Attenuated Schistosome Vaccine Evaluated in the Olive Baboon

AUTOR(ES)

Kariuki, Thomas M.

FONTE

American Society for Microbiology

RESUMO

Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

Documentos Relacionados

• Schistosome vaccine testing: lessons from the baboon model
• Classification of the coefficients of variation of parameters evaluated in Japanese quail experiments
• Vaccine Potential of Attenuated Mutants of Corynebacterium pseudotuberculosis in Sheep
• Stability of Live Attenuated Venezuelan Equine Encephalitis Vaccine
• Attenuated Vesicular Stomatitis Viruses as Vaccine Vectors