Parental adenovirus type 2 genomes recovered early or late in infection possess terminal proteins.
AUTOR(ES)
Straus, S E
RESUMO
At both early (3 h) and late (18 h) times after infection of KB cells with adenovirus 2, more than 90% of parental nuclear viral genomes exist as complexes which contain terminally linked proteins. Density shift experiments employing 5-bromo-2'-deoxyuridine indicate that these parental DNA molecules remain complexed with terminal proteins after DNA replication. The persistent linkage of proteins to the termini of intranuclear viral DNA suggests that these proteins have an essential role in adenovirus replication.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=353225Documentos Relacionados
- In vivo and in vitro synthesis of adenovirus type 2 early proteins.
- An immunodominant domain in adenovirus type 2 early region 1A proteins.
- Adenovirus type 2 terminal protein: purification and comparison of tryptic peptides with known adenovirus-coded proteins.
- Role of adenovirus type 2 early region 4 in the early-to-late switch during productive infection.
- Expression of adenovirus type 2 late genes in HeLa cells infected with adenovirus type 2 or adenovirus type 2-simian virus 40 hybrid viruses.