Partial Duplication in the “Hinge” Region of IgA1 Myeloma Proteins

AUTOR(ES)

Frangione, Blas

RESUMO

The aminoacid sequence of the “hinge” region of two human IgA1 myeloma proteins was found to be identical. A 30-residue fragment contains 3 cysteines, 12 prolines, and carbohydrate, and the sequence of a small segment of the hinge region is repeated at least twice. Since a deletion of 12-13 residues was found in the same region of an IgA2 myeloma protein, it is possible that IgA1 molecules are the result of the insertion of a partially duplicated gene segment in the immunoglobulin genes.

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