Participation of B-1 cells in the rejection of allografts. / Participação de células B-1 na rejeição de aloenxertos no camundongo.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

B-1 B cells are important producers of natural antibodies in mice and humans and, therefore, are considered as the first line of defense against pathogens. Because of that, their role in T-cell mediated immune responses is commonly underrated. However, recent studies have described the participation of B-1 cells in immediate and delayed-type hypersensitivity. The present work assessed the role of B-1 cells in the rejection of allografts in mice, an immune reaction mainly orchestrated by T cells. We have transplanted allogeneic skin and heart to wild-type and B-1 cell-deficient mice, and followed rejection kinetics. Skin graft-infiltrating cells were analyzed by flow cytometry. We observed a delay in rejection kinetics of B-1 cell-deficient mice when compared to wild-type mice. Adoptive transfer of B-1 cells into B-1 cell-deficient mice abrogated this delay. The longer survival observed in the absence of B-1 cells correlated with less CD8+ T cells infiltrating the grafts, as well as with more mast cells. Collectively, our results show the participation of B-1 cells in the allograft rejection process in mice, thus collaborating to the understanding of B- 1 cell biology.

ASSUNTO(S)

rejection of allografts in mice. b-1 cells 1. células b-1. 2. rejeição de enxerto. 3. inflamação. 4. mastócitos. 5. linfócitos t. microbiologia

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