Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.

AUTOR(ES)

Treanor, J J

RESUMO

The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.

Documentos Relacionados

• Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions.
• A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro.
• Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein.
• Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species
• Analysis of the posttranslational modifications of the influenza virus M2 protein.