Pathogenesis of chronic Chagas cardiomyopathy: the role of coronary microvascular derangements
AUTOR(ES)
Marin-Neto, Jose Antonio, Simoes, Marcus Vinicius, Rassi Junior, Anis
FONTE
Rev. Soc. Bras. Med. Trop.
DATA DE PUBLICAÇÃO
12/07/2013
RESUMO
There is ample experimental and clinical evidence of functional and structural microvascular abnormalities occurring in patients with Chagas cardiomyopathy, possibly due to the inflammatory process and/or autonomic disturbances caused by Trypanosoma cruzi infection. Those microvascular derangements are likely to constitute at least an ancillary factor that potentiates and amplifies the chronic inflammation in myocardial tissue. It is possible to devise appropriate therapeutic interventions aimed at reverting or slowing the progression of the microvascular abnormalities to positively affect the natural history of Chagas cardiomyopathy.
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