Pathogenesis of herpes simplex labialis: correlation of vesicle fluid interferon with lesion age and virus titer.

AUTOR(ES)

Spruance, S L

RESUMO

Of 51 patients with herpes simplex labialis, 50 had detectable interferon (IFN) in samples of lesion vesicle fluid. The median titer of vesicle fluid IFN was 8,200 U. and the range of values was 400 to 63,600 U. The amount of vesicle fluid IFN was correlated with lesion age (r = 0.32, P = 0.024) and vesicle fluid virus titer (r = 0.59, P = 0.00004), but not with the clinical severity of the disease. The presence of vesicle fluid IFN (1,500 to 28,600 U) in 15 lesions less than 12 h old emphasizes the need for early treatment in studies of antiviral agents for herpes simplex labialis.

Documentos Relacionados

• Pathogenesis of herpes simplex labialis: excretion of virus in the oral cavity.
• Pathogenesis of herpes simplex labialis: experimental induction of lesions with UV light.
• Preparation of herpes simplex virus of high titer.
• Acyclovir Cream for Treatment of Herpes Simplex Labialis: Results of Two Randomized, Double-Blind, Vehicle-Controlled, Multicenter Clinical Trials
• Correlation between detection of herpes simplex virus in oral secretions by PCR and susceptibility to experimental UV radiation-induced herpes labialis.