Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin-A levels but no association with fetuin-A polymorphisms
AUTOR(ES)
DOĞAN, Gülnihal Emrem, DEMİR, Turgut, LALOĞLU, Esra, SAĞLAM, Ebru, AKSOY, Hülya, YILDIRIM, Abdulkadir, AKÇAY, Fatih
FONTE
Braz. oral res.
DATA DE PUBLICAÇÃO
22/12/2016
RESUMO
ABSTRACT: Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus. Thus, we aimed to investigate a possible relationship between fetuin-A gene polymorphism and the presence of dental calculus. A possible relationship between serum, saliva and gingival crevicular fluid (GCF) levels of fetuin-A was also investigated. Fetuin-A c.742C > T and c.766C > G polymorphisms were investigated in 103 patients with or without dental calculus. Additionally, serum, saliva and GCF fetuin-A levels of patients were compared according to dental calculus presence. A significant difference was not observed in the distribution of the fetuin-A c.742C > T and c.766C > G polymorphisms between patients with or without dental calculus. Saliva and GCF fetuin-A concentrations of patients with dental calculus were statistically higher than those without dental calculus (P=0.001, P=0.036 respectively). According to our results, fetuin-A c.742C > T and c.766C > G polymorphisms were not associated with presence of dental calculus. However, higher GCF and saliva fetuin-A levels were detected in patients with dental calculus than in patients without dental calculus, which may result from an adaptive mechanism to inhibit mineral precipitation and eventually calculus formation.
Documentos Relacionados
- Fetuin-A levels in hyperthyroidism
- Fetuin-A Protects against Atherosclerotic Calcification in CKD
- Fetuin-A is related to syndesmophytes in patients with ankylosing spondylitis: a case control study
- Fetuin-A and Change in Body Composition in Older Persons
- Arginine and glutamate levels in the gingival crevicular fluid from patients with chronic periodontitis