Pattern recognition in nucleic acid sequences. II. An efficient method for finding locally stable secondary structures.
AUTOR(ES)
Kanehisa, M I
RESUMO
We present a method for calculating all possible single hairpin loop secondary structures in a nucleic acid sequence by the order of N2 operations where N is the total number of bases. Each structure may contain any number of bulges and internal loops. Most natural sequences are found to be indistinguishable from random sequences in the potential of forming secondary structures, which is defined by the frequency of possible secondary structures calculated by the method. There is a strong correlation between the higher G+C content and the higher structure forming potential. Interestingly, the removal of intervening sequences in mRNAs is almost always accompanied by an increase in the G+C content, which may suggest an involvement of structural stabilization in the mRNA maturation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=326132Documentos Relacionados
- Pattern recognition in nucleic acid sequences. I. A general method for finding local homologies and symmetries.
- An efficient method for matching nucleic acid sequences.
- An efficient method for finding repeats in molecular sequences.
- Efficient algorithms for folding and comparing nucleic acid sequences.
- Search algorithm for pattern match analysis of nucleic acid sequences.
