Patterns of spatiotemporal organization in an "ambiquitous" enzyme model.

AUTOR(ES)

Marmillot, P

RESUMO

Many enzymes in pathways such as glycolysis associate reversibly with cellular substructures. The spatiotemporal behavior of a "limit-cycle" oscillation model is studied under the condition that the "ambiquitous" oscillophor, phosphofructokinase, is partitioned between "bulk-phase" and "bound" forms in a heterogeneous system. Computer simulation demonstrates the occurrence of sustained, wave-like spatiotemporal patterns of chemical concentration in the bulk medium. Kinetic dissimilarity among the localized populations of bound enzyme leads to a "polarity" effect in the wave phenomenon. It is suggested that a key physiological role of the limit-cycle regime is to engender a rapid, site-to-site, signal-transmission modality in large eukaryotic (e.g., mammalian) cells.

Documentos Relacionados

• Patterns of Spatiotemporal Organization in an Allosteric Enzyme Model
• Double-stranded DNA organization in bacteriophage heads: an alternative toroid-based model.
• Organization of immunoglobulin heavy chain genes and allelic deletion model.
• Utilization patterns of cohorts of elderly clients: a structural equation model.
• Cryptosporidiosis in guinea pigs: an animal model.