pCREB in the Neonate Rat Olfactory Bulb Is Selectively and Transiently Increased by Odor Preference–Conditioned Training

AUTOR(ES)

McLean, John H.

FONTE

Cold Spring Harbor Laboratory Press

RESUMO

Early olfactory preference learning in rat pups occurs when novel odors are paired with tactile stimulation, for example stroking. cAMP-triggered phosphorylation of cAMP response element binding protein (pCREB) has been implicated as a mediator of learning and memory changes in various animals (Frank and Greenberg 1994). In the present study we investigate whether CREB is phosphorylated in response to conditioned olfactory training as might be predicted given the proposed role of the phosphorylated protein in learning.

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