Penetration of vancomycin into mediastinal and cardiac tissues in humans.
AUTOR(ES)
Martin, C
RESUMO
Vancomycin penetration into heart tissues (valves, myocardium, auricles, and pericardium) and mediastinal tissues (fat and sternal bone) was evaluated after two regimens of vancomycin administration. Ten patients were given 15 mg of vancomycin per kg of body weight before anesthesia. Ten other patients received the same dose and then a second 7.5-mg/kg dose at the time of initiation of cardiopulmonary bypass. Similar and satisfactory vancomycin tissue penetrations were observed in both groups. However, for some patients in the two groups, vancomycin levels in tissue were less than the MICs for potential pathogens (Staphylococcus aureus and Staphylococcus epidermidis).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=284467Documentos Relacionados
- Penetration of ceftriaxone (1 or 2 grams intravenously) into mediastinal and cardiac tissues in humans.
- Penetration of ciprofloxacin into heart valves, myocardium, mediastinal fat, and sternal bone marrow in humans.
- Penetration of ofloxacin into heart valves, myocardium, mediastinal fat, and sternal bone marrow in humans.
- Penetration of cefotaxime and desacetylcefotaxime into brain abscesses in humans.
- Penetration of Moxifloxacin into Healthy and Inflamed Subcutaneous Adipose Tissues in Humans