Penicillin is an active-site inhibitor for four genera of bacteria.
AUTOR(ES)
Yocum, R R
RESUMO
The hypothesis that penicillin acts as an active-site inhibitor cell wall biosynthesis was tested by a method of partial proteolytic mapping of penicillin-binding sites versus substrate-binding sites in cell wall D-alanine carboxypeptidases. This enzyme was obtained from four genera of bacteria, purified, and tested.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=216510Documentos Relacionados
- Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine
- Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I.
- Identification of active-site residues of the adenovirus endopeptidase.
- In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor
- Toxoid of Pseudomonas aeruginosa exotoxin A generated by deletion of an active-site residue.