Perception and Recognition Memory in Monkeys Following Lesions of Area TE and Perirhinal Cortex
AUTOR(ES)
Buffalo, Elizabeth A.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
Monkeys with lesions of perirhinal cortex (PR group) and monkeys with lesions of inferotemporal cortical area TE (TE group) were tested on a modified version of the delayed nonmatching to sample (DNMS) task that included very short delay intervals (0.5 sec) as well as longer delay intervals (1 min and 10 min). Lesions of the perirhinal cortex and lesions of area TE produced different patterns of impairment. The PR group learned the DNMS task as quickly as normal monkeys (N) when the delay between sample and choice was very short (0.5 sec). However, performance of the PR group, unlike that of the N group, fell to chance levels when the delay between sample and choice was lengthened to 10 min. In contrast to the PR group, the TE group was markedly impaired on the DNMS task even at the 0.5-sec delay, and three of four monkeys with TE lesions failed to acquire the task. The results provide support for the idea that perirhinal cortex is important not for perceptual processing, but for the formation and maintenance of long-term memory. Area TE is important for the perceptual processing of visual stimuli.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=311353Documentos Relacionados
- Anatomical organization of forward fiber projections from area TE to perirhinal neurons representing visual long-term memory in monkeys
- Dissociation Between the Effects of Damage to Perirhinal Cortex and Area TE
- Perirhinal Cortex Muscarinic Receptor Blockade Impairs Taste Recognition Memory Formation
- A Neural Circuit Analysis of Visual Recognition Memory: Role of Perirhinal, Medial, and Lateral Entorhinal Cortex
- Perirhinal Cortex Lesions Impair Context Aversion Learning