Peroxynitrite rapidly permeates phospholipid membranes
AUTOR(ES)
Marla, Sudhakar S.
FONTE
The National Academy of Sciences of the USA
RESUMO
Peroxynitrite (ONOO−) is a potent oxidant implicated in a number of pathophysiological processes. The activity of ONOO− is related to its accessibility to biological targets before its spontaneous decomposition (t1/2 ≈ 1 s at pH 7.4, 37°C). Using model phospholipid vesicular systems and manganese porphyrins as reporter molecules, we demonstrated that ONOO− freely crosses phospholipid membranes. The calculated permeability coefficient for ONOO− is ≈8.0 × 10−4 cm⋅s−1, which compares well with that of water and is ≈400 times greater than that of superoxide. We suggest that ONOO− is a significant biological effector molecule not only because of its reactivity but also because of its high diffusibility.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=24925Documentos Relacionados
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