Persistence of serum antibody to hepatitis B core antigen.
AUTOR(ES)
Hansson, B G
RESUMO
The purpose of the present study was to measure the amount of antibody to hepatitis B core antigen (anti-HBc) in different populations by the immunoelectroosmophoresis method. High titers of anti-HBc, up to 1/4,096, were found in the acute stage of hepatitis B virus infections and in the chronic carrier state of hepatitis B surface antigen. In cases of acute hepatitis the anti-HBc titers gradually declined to low levels but persisted for the observation time of 5 to 6 years. Individuals positive for antibodies to hepatitis B surface and core antigens selected from a Swedish "normal" population showed still lower anti-HBc titers, indicating that the hepatitis B infection had occurred earlier. The anti-HBc titers in sera drawn at intervals of 4 years from a group of hemophilia patients may indicate previous infection with replicating hepatitis B virus rather than immunization with noninfectious hepatitis B core antigen material.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=274741Documentos Relacionados
- Persistence of antibody to hepatitis B surface antigen.
- Passive hemagglutination test for antibody to hepatitis B core antigen.
- The value of screening blood donors for antibody to hepatitis B core antigen.
- Improvement in the specificity of assays for detection of antibody to hepatitis B core antigen.
- Application of a screening test for antibody the hepatitis B core antigen.