Pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in the neonatal macaque (Macaca nemestrina).
AUTOR(ES)
Keller, R D
RESUMO
Our objective was to determine whether age effects the pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in the neonatal pig-tailed macaque (Macaca nemestrina). The drug (5 mg/kg of body weight) was administered serially as a single intravenous bolus to the same four macaques at the ages of < 1 week, 1 month, and 4 months. Plasma clearance at < 1 week of age was significantly lower (P < 0.05) than the corresponding values at 1 month and 4 months. Our data indicate that the pharmacokinetics of stavudine change significantly with age in M. nemestrina.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=163043Documentos Relacionados
- In vivo maternal-fetal pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in pigtailed macaques (Macaca nemestrina).
- Prenatal and postpartum pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) and didanosine (dideoxyinosine) in pigtailed macaques (Macaca nemestrina).
- Zidovudine does not affect transplacental transfer or systemic clearance of stavudine (2',3'-didehydro-3'-deoxythymidine) in the pigtailed macaque (Macaca nemestrina).
- Effect of zidovudine on transplacental pharmacokinetics of ddI in the pigtailed macaque (Macaca nemestrina).
- Determination of Dosing Guidelines for Stavudine (2′,3′-Didehydro-3′-Deoxythymidine) in Children with Human Immunodeficiency Virus Infection