PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

AUTOR(ES)

Lejona, Sergio

FONTE

American Society for Microbiology

RESUMO

The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.

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