Physical and functional interaction between WT1 and p53 proteins.
AUTOR(ES)
Maheswaran, S
RESUMO
WT1 is a tumor-suppressor gene expressed in the developing kidney, whose inactivation leads to the development of Wilms tumor, a pediatric kidney cancer. WT1 encodes a transcription factor which binds to the EGR1 consensus sequence, mediating transcriptional repression. We now demonstrate that p53, the product of a tumor-suppressor gene with ubiquitous expression, physically associates with WT1 in transfected cells. The interaction between WT1 and p53 modulates their ability to transactivate their respective targets. In the absence of p53, WT1 acts as a potent transcriptional activator of the early growth response gene 1 (EGR1) site, rather than a transcriptional repressor. In contrast, WT1 exerts a cooperative effect on p53, enhancing its ability to transactivate the muscle creatine kinase promoter.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=46662Documentos Relacionados
- Physical and functional interaction between wild-type p53 and mdm2 proteins.
- Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency.
- Functional interaction between DP-1 and p53.
- Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.
- Discrimination of DNA binding sites by mutant p53 proteins.