Plasmid-Encoded Autolysin in Bacillus anthracis: Modular Structure and Catalytic Properties

AUTOR(ES)

Mesnage, Stéphane

FONTE

American Society for Microbiology

RESUMO

A Bacillus anthracis virulence plasmid-encoded peptidoglycan hydrolase (AmiA) with sequence similarity to N-acetylmuramoyl-l-alanine amidases hydrolyzes peptidoglycan independently of cell wall binding. Residues H341, E355, H415, and E486 are absolutely required for catalysis. Many AmiA paralogs are fused to different sorting signals, suggesting that these modular proteins result from domain shuffling.

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