Plasmid-Mediated Ampicillin Resistance in Haemophilus ducreyi
AUTOR(ES)
Brunton, James L.
RESUMO
Three of 19 strains of Haemophilus ducreyi, isolated during a recent outbreak of chancroid, were found to produce β-lactamase and to harbor a 6.0 × 106-dalton plasmid. Escherichia coli transformed with this plasmid acquired β-lactamase-mediated resistance to ampicillin. The guanine-plus-cytosine content of the plasmid was found to be 41 mol%. Restriction endonuclease digestion studies suggest that a relatively large portion of the Tn1 translocon is carried by this plasmid. Whereas this plasmid could not be transferred to H. influenzae by mating on membrane filters, a strain of H. ducreyi was able to receive and donate a 30 × 106-dalton ampicillin resistance plasmid from H. influenzae. The ability of H. ducreyi to receive and donate conjugative plasmids may result in the appearance of multiply resistant strains.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352648Documentos Relacionados
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