Plasmid-Mediated Beta-Lactamase Production in Neisseria gonorrhoeae
AUTOR(ES)
Elwell, Lynn P.
RESUMO
Several β-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae were examined for R plasmids. Penicillin-resistant strains isolated from men returning from the Far East and their contacts contained a 4.4 × 106-dalton plasmid in common. Transformation studies and the isolation of a spontaneous penicillin-susceptible segregant showed that the structural gene for β-lactamase was part of the 4.4 × 106-dalton plasmid. An additional penicillin-resistant gonococcal strain isolated in London was found to harbor a 3.2 × 106-dalton R plasmid. Deoxyribonucleic acid (DNA)-DNA duplex studies revealed that the penicillin-resistant gonococcal isolates contained a significant portion (about 40%) of the transposable DNA sequence, TnA, which includes the β-lactamase gene commonly found on R plasmids of the Enterobacteriaceae and Haemophilus influenzae.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352016Documentos Relacionados
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