PMX-622 (Polymyxin B-Dextran 70) Does Not Alter In Vitro Activities of 11 Antimicrobial Agents

AUTOR(ES)

Fuchs, Peter C.

FONTE

American Society for Microbiology

RESUMO

Because of its capacity to neutralize the lethality of gram-negative bacterial endotoxic lipopolysaccharides, PMX-622 (polymyxin B bound to dextran 70) is being developed for possible adjunctive therapy of gram-negative sepsis. In this study, it was determined that the in vitro antimicrobial activity of PMX-622 was minimal and that it does not interfere with the in vitro antimicrobial activity of 11 antibiotics commonly used to treat gram-negative infections.

Documentos Relacionados

• Therapeutic efficacy of a polymyxin B-dextran 70 conjugate in experimental model of endotoxemia.
• In vitro activities of streptomycin and 11 oral antimicrobial agents against clinical isolates of Klebsiella rhinoscleromatis.
• Pharmacodynamic Evaluation of the Neutralization of Endotoxin by PMX622 in Mice
• In vitro susceptibility of Borrelia burgdorferi to 11 antimicrobial agents.
• In vitro activities in new oxazolidinone antimicrobial agents against enterococci.