Poliformismo da haptoglobina, status de ferro e proteinas de fase aguda em pacientes infectados pelo virus da imunodeficiencia humana (HIV)

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

Haptoglobin (Hp) is a plasma protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1, Hp2-2) show distinctive efficiencies in their activities and have been related to susceptibility and/or outcome in different diseases, including HIV-infection. We compared the Hp genotype distribution between 387 Brazilian HIV-1-seropositive patients, sub-classified in A, B and C according to the Center for Disease Control-USA, and 142 healthy controls. We also investigated the influence of this polymorphism on the iron status (serum iron, ferritin, transferrin, transferrin saturation), the acute-phase proteins Hp, C-reative protein, fibrinogen and albumin, the viral loads and the CD4+ T-lymphocyte counts. There was no significant difference in the Hp genotypes distribution, neither between patients and controls nor among the clinical subgroups, although in the patient group the genotype distribution did not follow the Hardy-Weinberg equilibrium (p<0,05). Apart the lowest Hp concentrations showed by Hp2-2 individuals (patients and controls), no other significant difference or relevant correlation was observed, neither in the genotype frequency distribution nor in the biochemical parameters analyzed here, suggesting that the Hp polymorphism does not exert an important influence on these variables in the population investigated. The HP0 phenotype, correspondent to absent or reduced Hp in the plasma, was detected in 28% patients and 12% controls, but the molecular basis was not determined and, in part of the patients, this hypohaptoglobinemia can be secondary to hemolysis or liver dysfunction

ASSUNTO(S)

carga viral hiv (virus) haptoglobinas

ACESSO AO ARTIGO

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