Poliovirus protein 2BC increases cytosolic free calcium concentrations.
AUTOR(ES)
Aldabe, R
RESUMO
Poliovirus-infected cells undergo an increase in cytoplasmic calcium concentrations from the 4th h postinfection. The protein responsible for this effect was identified by the expression of different poliovirus nonstructural proteins in HeLa cells by using a recombinant vaccinia virus system. Synthesis of protein 2BC enhances cytoplasmic calcium concentrations in a manner similar to that observed in poliovirus-infected cells. To identify the regions in 2BC involved in modifying cytoplasmic calcium levels, several 2BC variants were generated. Regions present in both 2B and 2C are necessary to augment cellular free calcium levels. Therefore, in addition to inducing proliferation of membranous vesicles, poliovirus protein 2BC also alters cellular calcium homeostasis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=191886Documentos Relacionados
- Identification of Regions of Poliovirus 2BC Protein That Are Involved in Cytotoxicity
- Localized Apical Increases of Cytosolic Free Calcium Control Pollen Tube Orientation.
- Cytosolic-free calcium increases to greater than 100 micromolar in ATP-depleted proximal tubules.
- Long term treatment with theophylline increases malonyl dialdehyde plasma concentrations.
- Possible role of cytosolic free calcium concentrations in mediating insulin resistance of obesity and hyperinsulinemia.