Polyclonal activation of B-lymphocytes in vivo by Salmonella typhimurium lipoprotein.
AUTOR(ES)
Johnson, R B
RESUMO
Lipoprotein prepared from the outer membrane of Salmonella typhimurium is a polyclonal activator of murine B-lymphocytes. It was shown to be mitogenic for splenic cultures, stimulating increased incorporation of [3H]thymidine into DNA. When injected intravenously into mice, the lipoprotein induced splenomegaly and polyclonal B-cell activation. The latter was evident from an increase in the number of plaque-forming cells against trinitrophenylated sheep erythrocytes. Similar results were obtained with Escherichia coli lipoprotein.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=348120Documentos Relacionados
- Studies of Peripheral Blood T- and B-Lymphocytes in Acute Infections
- Studies of T- and B-Lymphocytes in Patients With Connective Tissue Diseases
- Studies of T- and B-Lymphocytes in Patients with Connective Tissue Diseases
- Studies on the Distribution of Surface Immunoglobulins on Human B-Lymphocytes
- Dynamics of B-lymphocytes in the lungs of mice exposed to aerosolized influenza virus.