Polymorphism in the structure of the yeast mitochondrial tRNA synthesis locus.
AUTOR(ES)
Miller, D L
RESUMO
Yeast mitochondrial DNA contains a genetic locus, called the tRNA synthesis locus, which codes for information necessary for mitochondrial tRNA biosynthesis. A 9S RNA molecule coded by this locus is thought to be the trans-acting element required for the removal of 5' extensions from tRNA precursors. The DNA coding for this RNA maps to a region of mitochondrial DNA known to contain strain specific restriction site polymorphisms. Comparison of the tRNA synthesis locus in two such strains by sequence analysis demonstrates that the restriction enzyme polymorphisms are due to the deletion/insertion of a 50 base pair GC-rich element in the 5' flanking sequence of the 9S RNA coding region. There are also several differences between the 9S RNA coding region of these two strains which do not interfere with the tRNA synthesis function.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=341039Documentos Relacionados
- A mitochondrial locus is necessary for the synthesis of mitochondrial tRNA in the yeast Saccharomyces cerevisiae.
- Characterization of tRNA genes in tRNA region II of yeast mitochondrial DNA
- Characterization of tRNA genes in tRNA region II of yeast mitochondrial DNA.
- Nucleotide sequences of ten mitochondrial tRNA genes in yeast Hansenula wingei.
- Transcription initiation and RNA processing of a yeast mitochondrial tRNA gene cluster.