Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection.

AUTOR(ES)

Takizawa, T

RESUMO

We reported previously that influenza virus infection induces the apoptotic death of HeLa cells associated with activation of the Fas gene. In this report, we show that transfection with a PKR having a point mutation in the catalytic domain of K at 296 to R suppressed both the augmented expression of Fas and cell death by influenza virus infection. These results suggested the involvement of PKR in influenza virus-induced cell death.

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