Possible Platelet Thrombi Formation in Dog and Human Femoral Arteries

AUTOR(ES)

Folts, John D.

RESUMO

Atherosclerosis is a ubiquitous condition that commonly produces vessel stenosis and progresses ultimately to vascular occlusion. It is thought by many that platelets collect on sites of atherosclerosis and exacerbate its progression. We have previously shown that platelet thrombi can form within 10 minutes in the stenosed coronary arteries of a dog and can produce acute cyclical reduction in blood flow measured with an electromagnetic flowmeter (EMF). This is followed by sudden restoration of flow as the platelet thrombus breaks loose and is carried distally (Circulation 54:365-370, 1976). In five dogs, blood flow was measured simultaneously in a femoral artery stenosed 70%, exposed proximally with an EMF, and monitored distally over intact skin with a Doppler ultrasonic flowmeter (DUF). Cyclical reductions in blood flow were detected by both the EMF and the DUF, presumably due to platelet thrombi forming in the stenosed femoral artery and then breaking loose and moving distally. These flow reductions could be consistently abolished with aspirin (ASA).

Documentos Relacionados

• The structure and growth of valve-pocket thrombi in femoral veins
• Effects of meningococcal and Escherichia coli capsular polysaccharides on human and dog platelet aggregation in vitro.
• Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.
• Histological demonstration of platelet thrombi with a double silver impregnation argyrophil stain.
• Alpha Adrenergic Vasoconstriction and Nitroglycerin Vasodilation of Large Coronary Arteries in the Conscious Dog