Postantibiotic Leukocyte Enhancement of Meropenem against Gram-Positive and Gram-Negative Strains

AUTOR(ES)
FONTE

American Society for Microbiology

RESUMO

The postantibiotic leukocyte enhancement (PALE) of meropenem in vitro in comparison with that of imipenem was evaluated with 24 recently isolated gram-positive and gram-negative strains. In general, pre-exposure to carbapenems (at four times the MIC for 2 h) led to increased polymorphonuclear cell phagocytic killing. The PALE of imipenem was generally significantly less than that observed with meropenem.

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