Postinfection control in T4 bacteriophage infection: inhibition of the rep function.
AUTOR(ES)
Ebisuzaki, K
RESUMO
We suggest that the general mechanism by which T4 phage turns off host macromolecular synthesis involves specific phage proteins which react with key components in the synthetic pathway. Support for this mechanism exists for the inhibition of host RNA synthesis. Here we note that the host rep function was inhibited after T4 phage infection. Since rep functions are known to be involved in host DNA replication, inhibition of rep might alter the course of host DNA replication.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=171085Documentos Relacionados
- Postinfection control by bacteriophage T4 of Escherichia coli recBC nuclease activity.
- Genetic analysis of bacteriophage T4 lysozyme structure and function.
- Site-specific cleavage of bacteriophage T4 DNA associated with the absence of gene 46 product function.
- Inhibition of T4 Bacteriophage Multiplication by Superinfecting Ghosts and the Development of Tolerance After Bacteriophage Infection
- Control of Gene Function in Bacteriophage T4 IV. Post-Transcriptional Shutoff of Expression of Early Genes