Potenciais evocados auditivos de tronco encefálico na Holoprosencefali / Auditory brainstem response in holoprosencephaly
AUTOR(ES)
Melissa Zattoni Antoneli
DATA DE PUBLICAÇÃO
2006
RESUMO
Objective: To evaluate and compare Auditory Brainstem Response (ABR) findings in patients with holoprosencephaly (HPE) and the HPE-like phenotype. Model: A prospective analysis comparing ABR results among three different groups: patients with classic HPE (GH), patients with HPE-like (GHL) and control group (GC), at a 5% significance level. Setting: Genetics Department, HRAC-USP. Participants: 57 patients, aged from 18 months to 22 years. Thirteen of them had classic HPE, 22 had HPE-like, and 22 were audiologically normal individuals, who joined the GC. Variables: Waves I, III and V absolute latencies; interpeak intervals I-V, III-V and I-III and wave V interear difference of ABR, in milisseconds, considering both right and left ears. Results: Mean values, in milisseconds, of absolute latencies and interpeaks recorded from right and left ears, respectivelly, were: Wave I: 2,21 and 2,19 (GH); 1,99 and 2,01 (GHL); 1,92 and 1,91 (GC). Wave III: 4,35 and 4,52 (GH); 4,04 and 4,04 (GHL); 3,97 and 3,94 (GC). Wave V: 6,47 and 6,51 (GH); 5,95 and 5,94 (GHL); 5,90 and 5,90 (GC). Interpeak I-V: 4,20 and 4,24 (GH); 3,94 and 3,92 (GHL); 3,97 and 3,97 (GC). Interpeak III-V: 2,27 and 2,07 (GH); 1,91 and 1,90 (GHL); 1,92 and 1,95 (GC). Interpeak I-III: 2,14 and 2,33 (GH); 1,03 and 2,01 (GHL); 2,04 and 2,01 (GC). Wave V interear difference were: 0,13 (GH); 0,06 (GHL) and 0,03 (GC). Conclusions: Results suggest that most patients with classic HPE have abnormalities detected by ABR testing, which are related to the severity of neurologic impairment. Otherwise, those with the HPE-like phenotype have few alterations, most likely resulting from middle ear pathologies that occur in presence of cleft palate.
ASSUNTO(S)
holoprosencefalia holoprosencephaly vias auditivas auditory evoked potentials auditory pathways brain stem potenciais evocados auditivos tronco encefálico
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