Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120.
AUTOR(ES)
Koonin, E V
RESUMO
Using computer methods for identification of amino acid motifs in sequence databases and multiple alignment, it is shown that human proliferation-associated nucleolar protein P120 contains a putative methyltransferase domain that is conserved in a group of bacterial proteins. It is hypothesized that P120 and the related prokaryotic proteins are rRNA methylases required for division of all types of cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=308198Documentos Relacionados
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