Preparation of procoligenoids from Escherichia coli heat-labile enterotoxins.

AUTOR(ES)

Finkelstein, R A

RESUMO

Heat-labile enterotoxins from Escherichia coli strains of porcine and human origin polymerize on heating to form high-molecular-weight aggregates, "procoligenoids," analogous to procholeragenoid derived from the cholera enterotoxin. This aggregation is accompanied by loss of biological activity (toxicity). Further heating results in the release of B-subunit oligomers, coligenoids, analogous to choleragenoid. Further studies are needed to determine whether, like procholeragenoid, the procoligenoids are superior antigens in stimulating gut immunity after parenteral administration.

Documentos Relacionados

• Immunological relationship of the B subunits of Campylobacter jejuni and Escherichia coli heat-labile enterotoxins.
• Antigenic similarity of heat-labile enterotoxins from diverse strains of Escherichia coli.
• Construction of a nontoxic fusion peptide for immunization against Escherichia coli strains that produce heat-labile and heat-stable enterotoxins.
• Comparison of heat-labile enterotoxins from porcine and human strains of Escherichia coli.
• Molecular heterogeneity of heat-labile enterotoxins from human and porcine enterotoxigenic Escherichia coli.