Preparation of PVP hydrogel nanoparticles using lecithin vesicles

AUTOR(ES)

Bueno, Vânia Blasques, Catalani, Luiz Henrique, Daghastanli, Katia Regina Perez, Cuccovia, Iolanda Midea, Chaimovich, Hernan

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2010

RESUMO

Hydrogels micro, sub-micro and nanoparticles are of great interest for drug encapsulation and delivery or as embolotherapic agents. In this work it is described the preparation of nano and sub-microparticles of pre-formed, high molecular weight and monomer free poly(N-vinyl-2-pyrrolidone) encapsulated inside the core of lecithin vesicles. The hydrogel particles are formed with a very narrow diameter distribution, of about 800 nm, and a moderate swelling ratio, of approximately 10.

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