Presence and formation of codeine and morphine in the rat.
AUTOR(ES)
Donnerer, J
RESUMO
Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver somniferum, caused a marked increase in the codeine and morphine levels in rat tissues. This provides evidence for a biosynthetic pathway to morphine in mammalians.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=323775Documentos Relacionados
- Morphine and codeine from mammalian brain.
- Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomes.
- Regional cerebral glucose utilization during morphine withdrawal in the rat.
- Supraspinal morphine and descending inhibitions acting on the dorsal horn of the rat.
- Presence of osteonectin/SPARC in mandibular condylar cartilage of the rat.