Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice
AUTOR(ES)
Thompson, Carol L.
FONTE
The National Academy of Sciences
RESUMO
To investigate the role of retinal-based pigments (opsins) in circadian photoreception in mice, animals mutated in plasma retinol binding protein were placed on a vitamin A-free diet and tested for photic induction of gene expression in the suprachiasmatic nucleus. After 10 months on the vitamin A-free diet, the majority of mice contained no detectable retinal in their eyes. These mice demonstrated fully intact photic signaling to the suprachiasmatic nucleus as measured by acute mPer mRNA induction in the suprachiasmatic nucleus in response to bright or dim light. The data suggest that a non-opsin pigment is the primary circadian photoreceptor in the mouse.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=58794Documentos Relacionados
- Contrasting impairments in IgM and IgG responses of vitamin A-deficient mice.
- Phenotype of arylsulfatase A-deficient mice: Relationship to human metachromatic leukodystrophy
- Impaired human responses to tetanus toxoid in vitamin A-deficient SCID mice reconstituted with human peripheral blood lymphocytes.
- Individuality in nutrition: effects of vitamin A-deficient and other deficient diets on experimental animals.
- Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.