Prevalence of H. pylori infection associated with clinical disorders diagnosed by upper gastrointestinal endoscopies, retrospective analysis of 1478 cases / Prevalência de infecção pelo Helicobacter pylori associada às afecções diagnosticadas por endoscopia digestiva alta: análise retrospectiva de 1478 casos

AUTOR(ES)

Sérgio Barbosa Marques

DATA DE PUBLICAÇÃO

2009

RESUMO

Introduction: Peptic ulcer prevalence and other esophageal and gastroduodenal disorders associated with H. pylori infection changed as a consequence of its eradication and the use of gastric acid secretor inhibitors. Purpose: To establish H. pylori infection prevalence associated with clinical disorders diagnosed by upper gastrointestinal endoscopy, and determine the risk factors. Methods: Data from 1478 patients were analyzed, and the endoscopic findings were correlated with the urease test results, age and gender. Patients with normal endoscopy were considered control group for statistical analysis of the risk factors, comprising a total of 272 individuals. Results: The overall prevalence of H. pylori infection was 53% (n=786), being higher between 31 and 40 years old. The most frequent endoscopic findings were gastritis (n=810, 54.8%), peptic ulcer (n=494, 33.4%), duodenitis (n=287, 19.4%) and esophagitis (n=217, 14.7%). Only nodular gastritis and peptic ulcer were associated with H. pylori infection (p<0.05). Erosive gastritis (70%) in the antrum (n=644; 78.5%) predominated in relation to pangastritis (n=166, 20.2%) and the ones in the corpus (n=19, 2.3%). Among peptic ulcer cases, 103 (7%) were gastric, 343 (23.2%) were duodenal and 48 (3.2%) were gastric and duodenal. Esophagitis usually was mild (grade A in 63.1%), 23.5% were moderate (grade B) and 13.3% were intense (grades C and D). H. pylori infection increased the risk of gastric and duodenal ulcers by 1.9 and 1.6-fold, respectively. Male gender and being older were risks of all the other conditions. Conclusion: H. pylori infection associated with older age and male gender were important determinants to gastrointestinal diseases outcome

ASSUNTO(S)

endoscopia gastrointestinal gastroenteropatias gastritis gastrite peptic ulcer Úlcera péptica gastroenteropathies helicobacter pylori/ epidemiologia endoscopy gastrointestinal helicobacter pylori / epidemiology

Documentos Relacionados

• PREVALÊNCIA DO HELICOBACTER PYLORI HÁ DEZ ANOS COMPARADA COM A ATUAL EM PACIENTES SUBMETIDOS À ENDOSCOPIA DIGESTIVA ALTA
• Prevalência da infecção pelo Helicobacter pylori em Fortaleza, Ceará
• Efeitos do remifentanil sobre despertar de pacientes sedados com propofol para endoscopia digestiva alta: estudo clínico randomizado
• Infecção pelo Helicobacter pylori: prevalência e associação com lesões gástricas
• Sedação em endoscopia digestiva alta: estudo comparativo com uso combinado de propofol e fentanil versus midazolam e fentanil