Problems posed by potential gonococcal vaccines viewed from the vantage point of a control agency.
AUTOR(ES)
Robbins, J B
RESUMO
Progress in the characterisation of Neisseria gonorrhoeae and other bacterial pathogens has suggested that immunoprophylaxis for gonorrhoea may be possible despite the well-known propensity for reinfection. Pili, outer membrane proteins, a capsular polysaccharide, and the lipopolysaccharide may be important gonococcal virulence factors, and immune components (probably antibodies) to more than one of these antigens may be required to confer immunity. A study of antigenic polymorphism of these structures should identify disease isolates more precisely and provide information about the relationship between variants of these gonococcal structures and gonococcal virulence.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1045384Documentos Relacionados
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